Cellular signalling mechanisms in B lymphocytes

Cellular signalling mechanisms of neural cell adhesion molecules.

Neural cell adhesion molecules of the immunoglobulin superfamily are multidomain proteins involved in important cellular events pertinent to development and adult neurological function. This review attempts to give a concise overview of the complex intracellular signaling pathways enabling neural cell adhesion molecules NCAM and L1 to regulate axon growth, guidance, and synaptic plasticity. Rec...

Mechanisms of TLR signaling and cooperation in B lymphocytes

Signalling mechanisms

Morgan Sheng’s research focuses on the molecular structure of synaptic junctions and on the mechanisms that regulate the formation, function and plasticity of excitatory synapses. Using biochemical and molecular genetic approaches, his lab has identified and characterized many of the specific proteins and protein– protein interactions that underlie the functional architecture of the postsynapti...

Multiple mechanisms of immune suppression by B lymphocytes.

Suppression of the immune system after the resolution of infection or inflammation is an important process that limits immune-mediated pathogenesis and autoimmunity. Several mechanisms of immune suppression have received a great deal of attention in the past three decades. These include mechanisms related to suppressive cytokines, interleukin (IL)-10 and transforming growth factor (TGF)-β, prod...

Impaired catecholaminergic signalling of B lymphocytes in patients with chronic rheumatic diseases.

OBJECTIVE To investigate further the influence of the autonomic nervous system on chronic rheumatic diseases. METHODS The density and affinity of beta2 adrenergic receptors (beta2R) on CD19+ lymphocytes in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc), as well as intracellular cAMP levels in patients with RA and SLE, were determined....